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mwbap16, conosciuta anche come mwbqINK4a, è una proteina codificata dal gene CDKN2A, il quale codifica anche per la proteina p14 (o mwbgp14arf).

• Funzione

• Interazioni

• Note

• Voci correlate

• Altri progetti

p16 appartiene alla famiglia delle CDKI, proteine che hanno la funzione di inibire l'azione delle mwcwchinasi dipendenti da ciclina (CDK), e quindi sono in grado di bloccare il ciclo cellulare ed impedire la mwdamitosi. Per tali funzioni il gene per questa proteina è definito un oncosoppressore ed è infatti ritrovato mutato o down-regolato in vari fenomeni tumorali tra cui il mwdqcancro al fegato. Poiché tra i target della proteina compare CDK4, il quale è un inibitore della proteina mwdwRB, questa proteina è in grado di incrementare l'attività della proteina e fa parte della via biochimica del RB. Inibisce la progressione del ciclo cellulare bloccandolo in fase Gap 1.

Sembra che il gene di p16 interagisca con SERTAD1,cite-ref-pmid15065884-1-0[1]cite-ref-pmid10580009-2-0[2] CCNG1,cite-ref-pmid12556559-3-0[3] DAXX,cite-ref-pmid18583933-4-0[4] mwjqP53,cite-ref-pmid14612427-5-0[5]cite-ref-pmid12446718-6-0[6]cite-ref-pmid9529249-7-0[7] E4F1,cite-ref-pmid12446718-6-1[6] CDK4,cite-ref-pmid15065884-1-1[1]cite-ref-pmid10580009-2-1[2]cite-ref-pmid17353931-8-0[8]cite-ref-pmid8805225-9-0[9]cite-ref-pmid8259215-10-0[10]cite-ref-pmid9228064-11-0[11] CDK6,cite-ref-pmid8805225-9-1[9]cite-ref-pmid9751050-12-0[12]cite-ref-pmid11739795-13-0[13] mwxqMdm2,cite-ref-pmid18583933-4-1[4]cite-ref-pmid14612427-5-1[5]cite-ref-pmid9529249-7-1[7]cite-ref-pmid12085228-14-0[14]cite-ref-pmid9529248-15-0[15] RPL11cite-ref-pmid14612427-5-2[5] e PPP1R9B.cite-ref-pmid11278317-16-0[16]

cite-note-pmid15065884-11. ↑ mwhaJunan Li, , Tsai Ming-Daw, Muscarella Peter, Ming-Daw Tsai e Peter Muscarella, mwhqmwhgThe nuclear protein p34SEI-1 regulates the kinase activity of cyclin-dependent kinase 4 in a concentration-dependent manner, in mwhwBiochemistry, vol.mwia 43, n.mwiq 14, United States, aprile 2004, pp.mwig 4394-9, mwiwDOI:mwja10.1021/bi035601s, mwjqISSNmwjg 0006-2960, mwlgPMIDmwlw mwma15065884.

cite-note-pmid10580009-22. ↑ mwngM Sugimoto, Ohtani N, Hampson L, Hampson I N, Shimamoto A, Furuichi Y, Okumura K, Niwa S e Taya Y, mwnwmwoaRegulation of CDK4 activity by a novel CDK4-binding protein, p34SEI-1, in mwoqGenes Dev., vol.mwog 13, n.mwow 22, UNITED STATES, novembre 1999, pp.mwpa 3027-33, mwpqDOI:mwpg10.1101/gad.13.22.3027, mwpwISSNmwqa 0890-9369, mwsaPMCmwsq mwsg317153, mwswPMIDmwta mwtq10580009.

cite-note-pmid12556559-33. ↑ mwuqLili Zhao, Winckler Sarah, Korgaonkar Chandrashekhar, Tompkins Van, Horne Mary C, , Quelle Dawn E e DE Quelle, mwugCyclin G1 has growth inhibitory activity linked to the ARF-Mdm2-p53 and pRb tumor suppressor pathways, in mwuwMol. Cancer Res., vol.mwva 1, n.mwvq 3, United States, Jan. 2003, pp.mwvg 195-206, mwvwISSNmwwa 1541-7786, mwyaPMIDmwyq mwyg12556559.

cite-note-pmid18583933-44. ↑ mw0aStacey M Ivanchuk, , Rutka James T e James T. Rutka, mw0qmw0gp14ARF interacts with DAXX: effects on HDM2 and p53, in mw0wCell Cycle, vol.mw1a 7, n.mw1q 12, United States, giugno 2008, pp.mw1g 1836-50, mw1wDOI:mw2a10.4161/cc.7.12.6025, mw2qPMIDmw2g mw2w18583933.

cite-note-pmid14612427-55. ↑ mw4wYanping Zhang, Bhat Krishna, Jin Aiwen, Allio Theresa, Burkhart William A, , Xiong Yue e Y. Xiong, mw5amw5qRibosomal Protein L11 Negatively Regulates Oncoprotein MDM2 and Mediates a p53-Dependent Ribosomal-Stress Checkpoint Pathway, in mw5gMol. Cell. Biol., vol.mw5w 23, n.mw6a 23, United States, dicembre 2003, pp.mw6q 8902-12, mw6gDOI:mw6w10.1128/MCB.23.23.8902-8912.2003, mw7aISSNmw7q 0270-7306, mw9qPMCmw9g mw9w262682, mw-aPMIDmw-q mw-g14612427.

cite-note-pmid12446718-66. ↑ mwaqaHelen Rizos, Badhwar Prerna, Woodruff Sarah, Becker Therese M, Rooney Robert J, , Kefford Richard F e RF Kefford, mwaqemwaqiAssociation of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition, in mwaqmJ. Biol. Chem., vol.mwaqq 278, n.mwaqu 7, United States, febbraio 2003, pp.mwaqy 4981-9, mwaqcDOI:mwaqg10.1074/jbc.M210978200, mwaqkISSNmwaqo 0021-9258, mwariPMIDmwarm mwarq12446718.

cite-note-pmid9529249-77. ↑ mwaroY Zhang, , Yarbrough W G e Wendell G Yarbrough, mwarsmwarwARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways, in mwar0Cell, vol.mwar4 92, n.mwar8 6, UNITED STATES, marzo 1998, pp.mwasa 725-34, mwaseDOI:mwasi10.1016/S0092-8674(00)81401-4, mwasmISSNmwasq 0092-8674, mwaswPMIDmwas0 mwas49529249.

cite-note-pmid17353931-88. ↑ mwatiRob M Ewing, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, Connor Liam e Li Michael, mwatmmwatqLarge-scale mapping of human protein–protein interactions by mass spectrometry, in mwatuMol. Syst. Biol., vol.mwaty 3, n.mwatc 1, England, 2007, p.mwatg 89, mwatkDOI:mwato10.1038/msb4100134, mwatsPMCmwatw mwat01847948, mwat4PMIDmwat8 mwaua17353931.

cite-note-pmid8805225-99. ↑ mwauyR Fåhraeus, Ball K L, Laín S, , Lane D P e David P. Lane, mwaucmwaugInhibition of pRb phosphorylation and cell-cycle progression by a 20-residue peptide derived from p16CDKN2/INK4A, in mwaukCurr. Biol., vol.mwauo 6, n.mwaus 1, ENGLAND, Jan. 1996, pp.mwauw 84-91, mwau0DOI:mwau410.1016/S0960-9822(02)00425-6, mwau8ISSNmwava 0960-9822, mwavgPMIDmwavk mwavo8805225.

cite-note-pmid8259215-1010. ↑ mwav4M Serrano, , Beach D e David Beach, mwav8mwawaA new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4, in mwawemwawiNature, vol.mwawm 366, n.mwawq 6456, ENGLAND, dicembre 1993, pp.mwawu 704-7, mwawyDOI:mwawc10.1038/366704a0, mwawgISSNmwawk 0028-0836, mwaxePMIDmwaxi mwaxm8259215.

cite-note-pmid9228064-1111. ↑ mwaxcK G Coleman, Morrissey D, Mulheron J, Sedman S A, Brinkley P, Price S, , Webster K R e KR Webster, mwaxgmwaxkIdentification of CDK4 sequences involved in cyclin D1 and p16 binding, in mwaxoJ. Biol. Chem., vol.mwaxs 272, n.mwaxw 30, UNITED STATES, luglio 1997, pp.mwax0 18869-74, mwax4DOI:mwax810.1074/jbc.272.30.18869, mwayaISSNmwaye 0021-9258, mwaykPMIDmwayo mways9228064.

cite-note-pmid9751050-1212. ↑ mway8A A Russo, Lee J O, Jeffrey P D, , Pavletich N P e Philip D. Jeffrey, mwazamwazeStructural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a, in mwazimwazmNature, vol.mwazq 395, n.mwazu 6699, ENGLAND, settembre 1998, pp.mwazy 237-43, mwazcDOI:mwazg10.1038/26155, mwazkISSNmwazo 0028-0836, mwaaiPMIDmwaam mwaaq9751050.

cite-note-pmid11739795-1313. ↑ mwaagP Kaldis, Tong L, Mäkelä T P, , Solomon M J e MJ Solomon, mwaakmwaaoCAK-independent Activation of CDK6 by a Viral Cyclin, in mwaasMol. Biol. Cell, vol.mwaaw 12, n.mwaa0 12, United States, dicembre 2001, pp.mwaa4 3987-99, mwaa8ISSNmwaba 1059-1524, mwabgPMCmwabk mwabo60770, mwabsPMIDmwabw mwab011739795.

cite-note-pmid12085228-1414. ↑ mwacePaula A Clark, , Peters Gordon e Gordon Peters, mwacimwacmMultiple interacting domains contribute to p14ARF mediated inhibition of MDM2, in mwacqOncogene, vol.mwacu 21, n.mwacy 29, England, luglio 2002, pp.mwacc 4498-507, mwacgDOI:mwack10.1038/sj.onc.1205558, mwacoISSNmwacs 0950-9232, mwadmPMIDmwadq mwadu12085228.

cite-note-pmid9529248-1515. ↑ mwadkJ Pomerantz, Liégeois N J, Silverman A, Alland L, Chin L, Potes J, Chen K, Orlow I e Lee H W, mwadomwadsThe Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53, in mwadwCell, vol.mwad0 92, n.mwad4 6, UNITED STATES, marzo 1998, pp.mwad8 713-23, mwaeaDOI:mwaee10.1016/S0092-8674(00)81400-2, mwaeiISSNmwaem 0092-8674, mwaesPMIDmwaew mwae09529248.

cite-note-pmid11278317-1616. ↑ mwafeM Vivo, Sansone F, Calabrò V, Parisi T, Borrelli L, Saviozzi S, , La Mantia G e G La Mantia, mwafimwafmThe human tumor suppressor arf interacts with spinophilin/neurabin II, a type 1 protein-phosphatase-binding protein, in mwafqJ. Biol. Chem., vol.mwafu 276, n.mwafy 17, United States, aprile 2001, pp.mwafc 14161-9, mwafgDOI:mwafk10.1074/jbc.M006845200, mwafoISSNmwafs 0021-9258, mwagmPMIDmwagq mwagu11278317.

• mwagkCiclo cellulare

• mwagsChinasi ciclina dipendente

• mwag0Proteina del retinoblastoma

Altri progetti

• Wikimedia Commons

• Wikimedia Commons contiene immagini o altri file su P16